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Mechanism and Effects of General Anaesthetics
Páchniková, Nina ; Groborz, Ondřej (advisor) ; Hrčka Krausová, Barbora (referee)
General anesthetics are key pharmacological agents that induce a reversible state of unconsciousness and allow surgical procedures to be performed. Despite their widespread use, the exact mechanism of action of general anesthetics remains partially unclear. This work provides a comprehensive review of historical and current theories of anesthetic function, examining general mechanisms of action and relevant target protein receptors including GABAA, glycine and NMDA receptors. It deals with the effects of specific anesthetics, namely etomidate, propofol, ketamine and isoflurane, examines their clinical effects, mechanisms of anesthetic action and interactions with various receptors. The thesis also discusses the implications of these findings, potentially informing future research directions. Key words: Anaesthetic, Pharmacology, Receptors, Review, Hypothesis
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